2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1433193-87-3
Molecular Formula:C₂₀H₁₅Cl₂N₅O
Molecular Weight:412.278
Hs Code.:

Synonyms:2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

There total 11 articles about 2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1428761-06-1
2-chloro-4-(ethylamino)pyrimidine-5-carbaldehyde

: 1432910-06-9
methyl 2-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)acetate

: 1433193-87-3
2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2015.12.059

Reference yield:

: 849934-94-7
methyl 2-(4-bromo-2-chlorophenyl)acetate

: 1433193-87-3
2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water; toluene / 100 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.tetlet.2015.12.059

Reference yield:

: 1138322-14-1
ethyl 2-chloro-4-(ethylamino)pyrimidine-5-carboxylate

: 1433193-87-3
2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / tetrahydrofuran / 40 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2015.12.059