r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin

Base Information

• Chemical Name: r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin
• CAS No.: 86839-47-6
• Molecular Formula: C₂₄H₂₅NO₃
• Molecular Weight: 375.467
• Mol file: 86839-47-6.mol

Synonyms:r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin

Chemical Property of r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin

There total 5 articles about r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Ethoxy-2-(p-methoxyphenyl)-1-methyl-4-phenyl-1,2-dihydro-4H-3,1-benzoxazin (86839-39-6) → r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin (86839-47-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃;

Reference yield:

p-Methoxybenzoesaeure-(α-hydroxy-α-phenyl-o-toluidid) (86839-15-8) → r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin (86839-47-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / PBr₃ / CH₂Cl₂

2: 90 percent / CH₂Cl₂ / 12 h / Ambient temperature

3: 55 percent / 0 °C

4: 89 percent / BuLi / tetrahydrofuran; hexane / -80 °C

With n-butyllithium; phosphorus tribromide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

2-(p-Methoxyphenyl)-4-phenyl-4H-3,1-benzoxazin (28586-60-9) → r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin (86839-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / CH₂Cl₂ / 12 h / Ambient temperature

2: 55 percent / 0 °C

3: 89 percent / BuLi / tetrahydrofuran; hexane / -80 °C

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

2-Ethoxy-2-(p-methoxyphenyl)-1-methyl-4-phenyl-1,2-dihydro-4H-3,1-benzoxazin

p-Methoxybenzoesaeure-(α-hydroxy-α-phenyl-o-toluidid)

2-(p-Methoxyphenyl)-4-phenyl-4H-3,1-benzoxazin

2-(p-Methoxybenzoylamino)benzophenon

Downstream raw materials:

1,2-Dihydro-2-(4-methoxyphenyl)-1-methyl-2-phenyl-3H-indol-3-on

1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on