1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on

Base Information

• Chemical Name: 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on
• CAS No.: 97004-65-4
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 97004-65-4.mol

Synonyms:1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on

Chemical Property of 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on

There total 15 articles about 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1-methyl-3-phenylindolin-2-one (3335-97-5) → 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on (97004-65-4)

Guidance literature:

With palladium diacetate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; for 16h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1055/a-1373-7017

Reference yield: 94.0%

3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one (15757-32-1) + methoxybenzene (100-66-3) → 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on (97004-65-4)

Guidance literature:

With nitrosonium tetrafluoroborate; In sulfolane; 1,2-dichloro-ethane; at 80 ℃; for 1h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.8b01495

Reference yield: 87.0%

1-methyl-3-phenylindolin-2-one (3335-97-5) + methoxybenzene (100-66-3) → 1,3-Dihydro-3-(4-methoxyphenyl)-1-methyl-3-phenyl-2H-indol-2-on (97004-65-4)

Guidance literature:

With graphene oxide; at 120 ℃; for 3h; Reagent/catalyst;

DOI:10.1002/adsc.201901224

upstream raw materials:

r-2-Ethoxy-t-3-hydroxy-2-(p-methoxyphenyl)-1-methyl-3-phenylindolin

1-methyl-3-phenylindolin-2-one

methoxybenzene

3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one