1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone

Base Information

• Chemical Name: 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone
• CAS No.: 185981-52-6
• Molecular Formula: C₃₆H₄₀O₃Si
• Molecular Weight: 548.797

Synonyms:1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone

Chemical Property of 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone

There total 7 articles about 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanol (185981-50-4) → 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone (185981-52-6)

Guidance literature:

With aluminum oxide; pyridinium chlorochromate; In dichloromethane; for 5.5h;

DOI:10.1021/jo960330v

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone (185981-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 20 h

2: 1.) EtMgBr, Mg / 1.) THF, 2.) reflux, 70 min; 40 min

With 1H-imidazole; ethylmagnesium bromide; magnesium; In N,N-dimethyl-formamide;

DOI:10.1021/jo960330v

Reference yield:

2-bromo-8-[1-hydroxy-2-(2-phenylethyl)phenylethyl]dibenzofuran (185981-48-0) → 1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanone (185981-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 20 h

2: 1.) EtMgBr, Mg / 1.) THF, 2.) reflux, 70 min; 40 min

With 1H-imidazole; ethylmagnesium bromide; magnesium; In N,N-dimethyl-formamide;

DOI:10.1021/jo960330v

upstream raw materials:

methyl 3-iodopropanoate

acetaldehyde

[1-(8-Bromo-dibenzofuran-2-yl)-2-(2-phenethyl-phenyl)-ethoxy]-tert-butyl-dimethyl-silane

1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-(2-phenethyl-phenyl)-ethyl]-dibenzofuran-2-yl}-ethanol

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