3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester

Base Information

• Chemical Name: 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester
• CAS No.: 143551-91-1
• Molecular Formula: C₁₇H₁₇IO₄
• Molecular Weight: 412.224
• Mol file: 143551-91-1.mol

Synonyms:3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester

Chemical Property of 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester

There total 7 articles about 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid (143551-90-0) + dimethyl sulfate (77-78-1) → 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester (143551-91-1)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)74692-2

Reference yield:

4-chlorobenzonitrile (100-00-5) → 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester (143551-91-1)

Guidance literature:

Multi-step reaction with 6 steps

2: 80 percent / pyridine, piperidine

3: 85 percent / H₂ / 10 percent Pd/C

4: H₂SO₄, NaNO₂ / 5 °C

5: KI

6: 96 percent / K₂CO₃ / acetone

With piperidine; pyridine; sulfuric acid; hydrogen; potassium carbonate; potassium iodide; sodium nitrite; palladium on activated charcoal; In acetone;

DOI:10.1016/S0040-4039(00)74692-2

Reference yield:

isovanillin (621-59-0) → 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid methyl ester (143551-91-1)

Guidance literature:

Multi-step reaction with 6 steps

2: 80 percent / pyridine, piperidine

3: 85 percent / H₂ / 10 percent Pd/C

4: H₂SO₄, NaNO₂ / 5 °C

5: KI

6: 96 percent / K₂CO₃ / acetone

With piperidine; pyridine; sulfuric acid; hydrogen; potassium carbonate; potassium iodide; sodium nitrite; palladium on activated charcoal; In acetone;

DOI:10.1016/S0040-4039(00)74692-2

upstream raw materials:

3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid

dimethyl sulfate

isovanillin

4-chlorobenzonitrile

Downstream raw materials:

(Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionic acid

methyl (Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionate

methyl-3-<4-methoxy-<3-<4-(2-(hydroxymethyl)ethynyl)phenoxy>phenyl>>propanoate