N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

Base Information

Chemical Name:N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide
CAS No.:127946-08-1
Molecular Formula:C₁₉H₂₉N₅O₃
Molecular Weight:375.471
Hs Code.:

Synonyms:N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

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Chemical Property of N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

Chemical Property:

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Technology Process of N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

There total 4 articles about N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)cyclohexyl]-carbamic acid benzyl ester

: 108-24-7
acetic anhydride

: 127946-07-0
N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

: 127946-08-1
N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 775.743 Torr;
DOI:10.1021/jm0605381

Reference yield:

: 4-Acetylamino-cyclohexanecarboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

: 127946-08-1
N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

Guidance literature:: With sodium hydroxide; at 80 ℃; for 0.5h; Yield given;
DOI:10.1021/jm00169a012

Reference yield:

: 81250-34-2
1,3-dipropyl-5,6-diaminouracil

: 127946-08-1
N-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)proyl>carbodiimide hydrochloride / H₂O / 2 h / Ambient temperature

2: 2.5 M aq. NaOH / 0.5 h / 80 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water;
DOI:10.1021/jm00169a012