3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

Base Information

Chemical Name:3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone
CAS No.:1608502-14-2
Molecular Formula:C₁₉H₂₀FNO₃
Molecular Weight:329.371
Hs Code.:

Synonyms:3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

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Chemical Property of 3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

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Technology Process of 3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

There total 3 articles about 3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1608502-21-1
4-bromomethylphenyl-3-fluoro-4-hydroxyphenylmethanone

: 1608502-14-2
3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

Guidance literature:: With triethylamine; In toluene; Reflux;
DOI:10.1016/j.ejmech.2014.03.042

Reference yield:

: 1147092-76-9
(4-(bromomethyl)phenyl)-(3-fluoro-4-methoxyphenyl)methanone

: 1608502-14-2
3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: triethylamine / toluene / Reflux

With boron tribromide; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.ejmech.2014.03.042

Reference yield:

: 1147092-74-7
(3-fluoro-4-methoxyphenyl)(p-tolyl)methanone

: 1608502-14-2
3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; benzoic peroxyanhydride / tetrachloromethane / Reflux

2: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: triethylamine / toluene / Reflux

With N-Bromosuccinimide; boron tribromide; triethylamine; benzoic peroxyanhydride; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2014.03.042