1147092-76-9

Upstream product

• 1147092-74-7 (3-fluoro-4-methoxyphenyl)(p-tolyl)methanone 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 1147092-72-5 {4-[(benzylmethylamino)methyl]phenyl}-(3-fluoro-4-methoxyphenyl)methanone 
• 1608502-21-1 4-bromomethylphenyl-3-fluoro-4-hydroxyphenylmethanone 
• 1608502-19-7 4-((2-dimethylaminoethyl)methylaminomethyl)phenyl-3-fluoro-4-hydroxyphenylmethanone 
• 1608502-18-6 3-fluoro-4-hydroxyphenyl-4-(4-methylpiperazin-1-ylmethyl)phenylmethanone 
• 1608502-17-5 3-fluoro-4-hydroxyphenyl-4-[4-(2-hydroxyethyl)piperidin-1-ylmethyl]phenylmethanone 
• 1608502-16-4 4-(4-benzylpiperazin-1-ylmethyl)phenyl-3-fluoro-4-hydroxyphenylmethanone 
• 1608502-15-3 3-fluoro-4-hydroxyphenyl-4-(4-phenylpiperazin-1-ylmethyl)phenylmethanone 
• 1608502-14-2 3-fluoro-4-hydroxyphenyl-4-(4-hydroxypiperidin-1-ylmethyl)phenylmethanone 
• 1608502-13-1 3-fluoro-4-hydroxyphenyl-4-(2-hydroxyethyl)methylaminomethylphenylmethanone 
• 1608502-12-0 3-fluoro-4-hydroxyphenyl-4-((3-hydroxybenzyl)(methyl)aminomethyl)phenylmethanone 
• 1608502-10-8 4-((benzyl(methyl)amino)methyl)phenyl-3-fluoro-4-hydroxyphenylmethanone 

Relevant academic research and scientific papers

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing

The inhibition of steroidogenic cytochrome P450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17α hydroxylase/17,20 lyase) are curr

Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease

In an effort to develop multipotent agents against β-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues. Among the series, derivatives 5 and 12, carrying chemically different amino functions, showed a balanced micromolar potency against the selected targets. In particular, compound 12, completely devoid of toxic effects, seems to be a promising lead for obtaining effective anti-AD drug candidates.

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

Starting from a structure-based drug design, new acetylcholinesterase inhibitors were designed and synthesized as analogues of donepezil. The compounds were composed by an aromatic function and a tertiary amino moiety connected by a suitable spacer. In pa