N-(3-phenylpropyl)cyclohexanamine

Base Information

• Chemical Name: N-(3-phenylpropyl)cyclohexanamine
• CAS No.: 345224-80-8
• Molecular Formula: C₁₅H₂₃N
• Molecular Weight: 217.354
• Mol file: 345224-80-8.mol

Synonyms:N-(3-phenylpropyl)cyclohexanamine

Chemical Property of N-(3-phenylpropyl)cyclohexanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-(3-phenylpropyl)cyclohexanamine

There total 19 articles about N-(3-phenylpropyl)cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-Phenylpropan-1-amine (2038-57-5) + aniline (62-53-3) → N-(3-phenylpropyl)cyclohexanamine (345224-80-8)

Guidance literature:

With hydrogen; In neat (no solvent); at 50 ℃; for 72h;

DOI:10.1055/s-0037-1611341

Reference yield: 91.0%

3-Phenylpropan-1-amine (2038-57-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-(3-phenylpropyl)cyclohexanamine (345224-80-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1246/cl.2001.712

Reference yield: 81.0%

Cyclohexyl iodide (626-62-0) + 3-Phenylpropan-1-amine (2038-57-5) → N-(3-phenylpropyl)cyclohexanamine (345224-80-8)

Guidance literature:

With copper(l) iodide; tert-butylimino-tri(pyrrolidino)phosphorane; 1,1'-bi-2-naphthol; In N,N-dimethyl-formamide; acetonitrile; at -10 ℃; for 40h; Reagent/catalyst; Irradiation; Large scale;

DOI:10.1021/jacs.7b09582

upstream raw materials:

quinoline

2-cyclohexylamino-4-phenyl-butyric acid

9H-fluorene

N-(3-phenylallylidene)cyclohexanamine

Downstream raw materials:

N-cyclohexyl-N-(3-phenylpropyl)-4-methylbenzenesulfonamide

3-phenyl-propionaldehyde

Refernces

• 1、 Suzuki, Aya,Miyamura, Hiroyuki,Kobayashi, Shu. "Highly Selective Reductive Cross-Amination between Aniline or Nitroarene Derivatives and Alkylamines Catalyzed by Polysilane-Immobilized Rh/Pt Bimetallic Nanoparticles". supporting information. p. 387 - 392. Retrieved 2019/02/26.
• 2、 Matier, Carson D.,Schwaben, Jonas,Peters, Jonas C.,Fu, Gregory C.. "Copper-Catalyzed Alkylation of Aliphatic Amines Induced by Visible Light". supporting information. p. 17707 - 17710. Retrieved 2017/12/26.