Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

Base Information

Chemical Name:Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate
CAS No.:1202577-00-1
Molecular Formula:C₂₁H₁₈F₃NO₄
Molecular Weight:405.373
Hs Code.:

Synonyms:Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

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Chemical Property of Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

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Technology Process of Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

There total 3 articles about Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1202576-99-5
(22A) 4-{[8-(Trifluoromethyl)quinolin-4-yl]oxy}benzaldehyde

: 141-78-6
ethyl acetate

: 1202577-00-1
Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

Guidance literature:: ethyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

(22A) 4-{[8-(Trifluoromethyl)quinolin-4-yl]oxy}benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1202577-00-1
Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 23779-97-7
4-chloro-8-(trifluoromethyl)quinoline

: 1202577-00-1
Ethyl 3-hydroxy-3-(4{[8-(trifluoromethyl)quinolin-4-yl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;