N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

Base Information

Chemical Name:N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide
CAS No.:1431772-90-5
Molecular Formula:C₂₅H₂₇N₇O₂
Molecular Weight:457.535
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

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Chemical Property of N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

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Technology Process of N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

There total 6 articles about N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1431772-59-6
3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 141-43-5
ethanolamine

: 1431772-90-5
N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

Guidance literature:: With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 480425-35-2
methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1431772-90-5
N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 6 h / 100 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; bromine / methanol / 16.5 h / 20 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

5.2: pH 4

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 16 h / 20 °C

With 1-methyl-1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; bromine; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; XPhos; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1431773-69-1
methyl 3-(6-aminopyridazin-3-yl)benzoate

: 1431772-90-5
N-(2-hydroxyethyl)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; bromine / methanol / 16.5 h / 20 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

4.2: pH 4

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 16 h / 20 °C

With 1-methyl-1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; bromine; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;