(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

Chemical Name:(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester
CAS No.:205240-86-4
Molecular Formula:C₂₀H₂₈O₄
Molecular Weight:332.44
Hs Code.:

Synonyms:(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

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Chemical Property of (R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

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Technology Process of (R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

There total 13 articles about (R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121618-70-0,121618-62-0
(S)-2-(tert-butyldimethylsilanyloxymethyl)-2,6-dimethyl-hept-5-enal

: 205240-86-4
(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 98 percent / sodium borohydride / ethanol / 0 °C

2: 97 percent / i-Pr₂NEt, 4-DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

4: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

5: n-Bu₄NF / tetrahydrofuran / Ambient temperature

6: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

7: NaH / 1,2-dimethoxy-ethane / Ambient temperature

8: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

9: 85 percent / HCl, EtOH / 60 °C

10: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

11: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

12: pyridine, 4-DMAP / Ambient temperature

13: DBU / 110 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 162823-46-3
tert-Butyl-((R)-2-methoxymethoxymethyl-2,6-dimethyl-hept-5-enyloxy)-dimethyl-silane

: 205240-86-4
(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

2: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

3: n-Bu₄NF / tetrahydrofuran / Ambient temperature

4: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

5: NaH / 1,2-dimethoxy-ethane / Ambient temperature

6: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

7: 85 percent / HCl, EtOH / 60 °C

8: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

9: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

10: pyridine, 4-DMAP / Ambient temperature

11: DBU / 110 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 162823-45-2
(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-2,6-dimethyl-hept-5-en-1-ol

: 205240-86-4
(R)-3-[3-(4-Methoxy-phenoxy)-propyl]-3-methyl-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 97 percent / i-Pr₂NEt, 4-DMAP / CH₂Cl₂ / Ambient temperature

2: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

3: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

4: n-Bu₄NF / tetrahydrofuran / Ambient temperature

5: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

6: NaH / 1,2-dimethoxy-ethane / Ambient temperature

7: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

8: 85 percent / HCl, EtOH / 60 °C

9: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

10: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

11: pyridine, 4-DMAP / Ambient temperature

12: DBU / 110 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;