2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Base Information

Chemical Name:2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide
CAS No.:1564256-46-7
Molecular Formula:C₂₃H₂₇ClN₆O₂S
Molecular Weight:487.025
Hs Code.:

Synonyms:2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Suppliers and Price of 2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

There total 7 articles about 2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.3%

: 761440-11-3
2-((2-amino-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

: 919099-24-4
rac-8-amino-1,3-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

: 1564256-46-7
2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-60-5
C₁₈H₁₈N₂O₂

: 1564256-46-7
2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1,2-dichloro-ethane / 2 h / Reflux

2.1: methanol / Reflux

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 1 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h

5.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; potassium carbonate; acetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-63-8
C₁₁H₁₂N₂O₂

: 1564256-46-7
2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h

1.2: 1 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h

3.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; acetic acid; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml400373j