761440-11-3

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 23530-40-7 N-methyl-2-nitrobenzenesulfonamide 
• 16288-77-0 2-amino-N-methylbenzenesulfonamide 
• 5750-76-5 2,4,5-trichloropyrimidine 

Downstream Products

• 1022954-36-4 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide 
• 1022963-23-0 2-[5-chloro-2-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-6-ylamino)pyrimidin4-ylamino]-N-methyl-benzenesulfonamide 
• 1022954-60-4 {7-[5-chloro-4-(2-methylsulfamoyl-phenylamino)-pyrimidin-2-ylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid methyl ester 
• 1346447-82-2 2-((5-chloro-2-((3-nitrophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 1564256-46-7 2-((5-chloro-2-((3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 1346447-84-4 N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide 
• 1346447-83-3 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 

Relevant academic research and scientific papers

AXL KINASE INHIBITORS AND USE OF THE SAME

Tartrate salts of the compound of structure (I), crystalline forms thereof, and therapeutic applications thereof for treating solid tumors (e.g., advanced solid tumor) or hematopoietic cancers. Also provided herein are methods for synthesizing the tartrat

Compound used as ALK (anaplastic lymphoma kinase) inhibitor and application thereof

The invention discloses a compound shown in a formula I, and pharmaceutically acceptable salts, stereoisomers, solvates or predrugs. The symptoms are defined in claim requirements. The compound shownin the formula I has good inhibiting activity on ALK (anaplastic lymphoma kinase), and can be used for preparing medicines for adjusting the activity of the ALK activity or treating the ALK-related diseases, especially nonsmall-cell lung cancer drugs. (The formula I is shown in the attached figure.).

COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH

Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.

FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS

Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.