1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

Base Information

Chemical Name:1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone
CAS No.:129593-06-2
Molecular Formula:C₂₅H₂₆N₂O₂
Molecular Weight:386.494
Hs Code.:

Synonyms:1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

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Chemical Property of 1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

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Technology Process of 1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

There total 6 articles about 1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 129593-05-1
(6aS,11bS)-3-Benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazole

: 75-36-5
acetyl chloride

: 129593-06-2
1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jo00307a019

Reference yield:

: 64297-96-7
N-(iodoacetyl)benzylamine

: 129593-06-2
1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1) KH / 1) THF, 5 min, r.t., 2) 10 min

2: 40 percent / conc. HCl, H₂ / 10percent Pd/C / CHCl₃; ethanol / 20 h / 2585.7 Torr / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 12 h / Heating

4: 75 percent / triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jo00307a019

Reference yield:

: 129593-02-8
(3aS,6aR,11bR)-3,7-Dibenzyl-3a-hydroxy-3a,4,5,6,6a,7-hexahydro-3H-pyrrolo[2,3-d]carbazol-2-one

: 129593-06-2
1-((6aR,11bR)-7-Acetyl-3-benzyl-2,3,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazol-4-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / conc. HCl, H₂ / 10percent Pd/C / CHCl₃; ethanol / 20 h / 2585.7 Torr / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 12 h / Heating

3: 75 percent / triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jo00307a019