2',4'-ditetrahydropyranyloxychalcone epoxide

Base Information

• Chemical Name: 2',4'-ditetrahydropyranyloxychalcone epoxide
• CAS No.: 136258-03-2
• Molecular Formula: C₂₅H₂₈O₆
• Molecular Weight: 424.494
• Mol file: 136258-03-2.mol

Synonyms:2',4'-ditetrahydropyranyloxychalcone epoxide

Chemical Property of 2',4'-ditetrahydropyranyloxychalcone epoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',4'-ditetrahydropyranyloxychalcone epoxide

There total 7 articles about 2',4'-ditetrahydropyranyloxychalcone epoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2',4'-ditetrahydropyranyloxychalcone (136258-02-1) → 2',4'-ditetrahydropyranyloxychalcone epoxide (136258-03-2)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In methanol; for 1.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → 2',4'-ditetrahydropyranyloxychalcone epoxide (136258-03-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 62 percent / pyridine / 6 h

2: 92 percent / BF₃*OEt₂ / diethyl ether; CHCl₃ / 4 h / Heating

3: 90 percent / 2 M aq.NaOH / dioxane / 36 h / Ambient temperature

4: 31 percent / pyridinium p-toluenesulphonate (PPTS) / CH₂Cl₂ / 4 h

5: 40 percent / AgNO₃, Ag₂O / acetonitrile; H₂O / 0.08 h / 0 °C

6: 79 percent / aq.KOH / methanol / 20 h / Ambient temperature

7: 91 percent / H₂O₂, 2 M aq.NaOH / methanol / 1.5 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; pyridinium p-toluenesulfonate; silver nitrate; silver(l) oxide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

2,4-dibenzoyloxyacetophenone (66832-97-1) → 2',4'-ditetrahydropyranyloxychalcone epoxide (136258-03-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 92 percent / BF₃*OEt₂ / diethyl ether; CHCl₃ / 4 h / Heating

2: 90 percent / 2 M aq.NaOH / dioxane / 36 h / Ambient temperature

3: 31 percent / pyridinium p-toluenesulphonate (PPTS) / CH₂Cl₂ / 4 h

4: 40 percent / AgNO₃, Ag₂O / acetonitrile; H₂O / 0.08 h / 0 °C

5: 79 percent / aq.KOH / methanol / 20 h / Ambient temperature

6: 91 percent / H₂O₂, 2 M aq.NaOH / methanol / 1.5 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; pyridinium p-toluenesulfonate; silver nitrate; silver(l) oxide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1016/S0040-4020(01)80960-1

upstream raw materials:

2',4'-ditetrahydropyranyloxychalcone

2',4'-dihydroxy-4-acetophenone

2,4-dibenzoyloxyacetophenone

2',4'-dihydroxyacetophenone ethylene hemithioketal

Downstream raw materials:

2',4'-dihydroxychalcone epoxide