3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Base Information

Chemical Name:3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one
CAS No.:162174-72-3
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

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Chemical Property of 3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

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Technology Process of 3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

There total 15 articles about 3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 162170-49-2
3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

: 162174-72-3
3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: With hydrogen; palladium on carbon; In methanol; for 2h; under 2068.65 Torr;

Reference yield:

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 162174-72-3
3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / TsOH*H₂O, 3 A molecular sieves / CH₂Cl₂ / 6 h / Heating

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 3 h

3: 1.) LDA*THF / 1.) THF, cyclohexane, from -78 deg C to -20 deg C, 45 min, 2.) THF, cyclohexane, from -78 deg C to -20 deg C, 1 h

4: 91 percent / HCO₂NH₄ / 5percent Pd/C / methanol / 1.5 h

With 3 A molecular sieve; ammonium formate; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm950888f

Reference yield:

: 162174-77-8
m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

: 162174-72-3
3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / TsOH*H₂O, 3 A molecular sieves / CH₂Cl₂ / 6 h / Heating

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 3 h

3: 1.) LDA*THF / 1.) THF, cyclohexane, from -78 deg C to -20 deg C, 45 min, 2.) THF, cyclohexane, from -78 deg C to -20 deg C, 1 h

4: 91 percent / HCO₂NH₄ / 5percent Pd/C / methanol / 1.5 h

With 3 A molecular sieve; ammonium formate; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm950888f