3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Base Information

Chemical Name:3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one
CAS No.:162170-49-2
Molecular Formula:C₃₃H₃₃NO₅
Molecular Weight:523.629
Hs Code.:

Synonyms:3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

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Chemical Property of 3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

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Technology Process of 3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

There total 16 articles about 3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 162174-71-2
6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

: 162174-77-8
m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

: 162170-49-2
3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 21h; Heating;
DOI:10.1021/jm00018a023

Reference yield:

: 3481-02-5
cyclopropyl phenyl ketone

: 162170-49-2
3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / fuming 90percent nitric acid / 0.17 h / -10 °C

2: hydrogen / 5percent platinum on carbon / methanol / 5 h / 760 Torr

3: diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

4: 96 percent / sodium borohydride / tetrahydrofuran; ethanol / 3 h / Ambient temperature

5: 56 percent / p-toluenesulfonic acid monohydrate / benzene / 21 h / Heating

With sodium tetrahydroborate; hydrogen; nitric acid; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/jm00018a023

Reference yield:

: 5680-51-3
cyclopropyl-(3-nitrophenyl)methanone

: 162170-49-2
3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5percent platinum on carbon / methanol / 5 h / 760 Torr

2: diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

3: 96 percent / sodium borohydride / tetrahydrofuran; ethanol / 3 h / Ambient temperature

4: 56 percent / p-toluenesulfonic acid monohydrate / benzene / 21 h / Heating

With sodium tetrahydroborate; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/jm00018a023