[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

Base Information

Chemical Name:[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine
CAS No.:1232397-23-7
Molecular Formula:C₂₄H₂₆N₆O
Molecular Weight:414.51
Hs Code.:

Synonyms:[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

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Chemical Property of [7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

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Technology Process of [7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

There total 8 articles about [7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1232788-41-8
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

: 5720-06-9
2-Methoxyphenylboronic acid

: 1232397-23-7
[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm200758k

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232397-23-7
[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm200758k

Reference yield:

: 1233184-54-7
7-bromo-2-(methylsulfinyl)pyrrolo[2, 1-f][1,2,4]triazine

: 1232397-23-7
[7-(2-methoxy-phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

2: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm200758k