1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile

Base Information

• Chemical Name: 1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile
• CAS No.: 216311-16-9
• Molecular Formula: C₁₅H₁₉F₂N₃
• Molecular Weight: 279.333
• DSSTox Substance ID: DTXSID201166920

Synonyms:SCHEMBL7523663;DTXSID201166920;1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile;216311-16-9

Chemical Property of 1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 279.15470394
• Heavy Atom Count: 20
• Complexity: 357

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1(C#N)C2=C(C=C(C=C2)F)F)CCCN

Technology Process of 1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile

There total 1 articles about 1-(3-Aminopropyl)-4-(2,4-difluorophenyl)-4-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(3-aminopropyl)-4-(2,4-difluorophenyl)-piperidine-4-carbonitrile (216311-16-9)

Guidance literature:

Reference yield:

(+)-3-(4-nitrophenoxycarbonyl)-4-(3,4-difluorophenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester (191353-92-1) + 1-(3-aminopropyl)-4-(2,4-difluorophenyl)-piperidine-4-carbonitrile (216311-16-9) → (+)-1-{3-[4-cyano-4-(2,4-difluoro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-4-methoxymethyl-5-methoxycarbonyl-2-pyrimidone (216310-76-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; dichloromethane;

Reference yield:

4-(3,4-DIFLUOROPHENYL)-2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID (265985-98-6) + 1-(3-aminopropyl)-4-(2,4-difluorophenyl)-piperidine-4-carbonitrile (216311-16-9) → 4-(R)-(3,4-difluorophenyl)-6-methyl-3,4-dihydro-2-pyridinone-5-carboxylic acid{3-[4-(2,4-difluorophenyl)-4-cyano-piperidine-1-yl]-propyl}amide

Guidance literature:

Downstream raw materials:

(+)-1-{3-[4-cyano-4-(2,4-difluoro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-4-methoxymethyl-5-methoxycarbonyl-2-pyrimidone

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