4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac

Base Information

Chemical Name:4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac
CAS No.:265985-98-6
Molecular Formula:C₁₃H₁₁F₂NO₃
Molecular Weight:267.232
Hs Code.:
Mol file:265985-98-6.mol

Synonyms:4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac;4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic acid;4-(3,4-Difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid

Suppliers and Price of 4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac

Chemical Property:

PSA：69.89000
LogP:2.20280

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac

There total 3 articles about 4-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 265985-99-7
4-(3,4-difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid benzyl ester

: 265985-98-6
4-(3,4-DIFLUOROPHENYL)-2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID

Guidance literature:: With palladium on activated charcoal; hydrogen;
DOI:10.1016/S0960-894X(99)00696-4

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 265985-98-6
4-(3,4-DIFLUOROPHENYL)-2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID

Guidance literature:: Multi-step reaction with 2 steps

1: Meldrum's acid; AcOH

2: H₂; Pd/C

With palladium on activated charcoal; cycl-isopropylidene malonate; hydrogen; acetic acid; 1: Condensation / 2: Hydrogenolysis;
DOI:10.1016/S0960-894X(99)00696-4