(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

Base Information

Chemical Name:(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester
CAS No.:960403-07-0
Molecular Formula:C₁₄H₁₅FN₂O₂
Molecular Weight:262.284
Hs Code.:

Synonyms:(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

Chemical Property:

Boiling Point:408.9±30.0 °C(Predicted)
Density:1.17±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

There total 2 articles about (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 371-62-0
2-fluoroethanol

: 61045-91-8
(R)-Metomidate

: 960403-07-0
(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In toluene; for 18h;
DOI:10.1021/jm800012w

Reference yield: 4.0%

: 762-49-2
2-fluoroethyl bromide

: 960403-07-0
(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

Guidance literature:: (R)-(+)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid; With tetra(n-butyl)ammonium hydroxide; In dichloromethane;

2-fluoroethyl bromide; In N,N-dimethyl-formamide; at 150 ℃; for 4.5h;

Reference yield:

: 960403-07-0
(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid2-fluoroethyl ester

: 2-(18F)fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate

Guidance literature:: With ¹⁸F-fluoride; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; at 110 ℃; for 0.166667h; Automated synthesizer;
DOI:10.1002/jlcr.1742