3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

Base Information

Chemical Name:3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide
CAS No.:1548515-42-9
Molecular Formula:C₂₃H₂₁Cl₂FN₂O₂
Molecular Weight:447.336
Hs Code.:

Synonyms:3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

Chemical Property:

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Technology Process of 3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

There total 7 articles about 3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135779-54-3
C₁₆H₁₆Cl₂N₂O₂

: 459-46-1
4-Fluorobenzyl bromide

: 1548515-42-9
3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 10h;
DOI:10.1016/j.cclet.2013.11.033

Reference yield:

: 3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)propanoic acid

: 104-94-9
4-methoxy-aniline

: 1548515-42-9
3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 2h;
DOI:10.1016/j.cclet.2016.10.016

Reference yield:

: 95-76-1
m,p-dichloroaniline

: 1548515-42-9
3-((3,4-dichlorophenyl)(4-fluorobenzyl)amino)-N-(4-methoxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 3 h / 50 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 90 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2013.11.033