2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

Base Information

Chemical Name:2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine
CAS No.:1610472-30-4
Molecular Formula:C₁₇H₁₇FN₄O
Molecular Weight:312.347
Hs Code.:

Synonyms:2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

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Chemical Property of 2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

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Technology Process of 2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

There total 5 articles about 2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1610472-33-7
{2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzyl}carbamic acid tert-butyl ester

: 1610472-30-4
2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 864262-97-5
tert-butyl N-[(4-bromo-2-fluoro-phenyl)methyl]carbamate

: 1610472-30-4
2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 20 h / 100 °C / Inert atmosphere; Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 150 °C / Microwave irradiation

3: methanol / Reflux; Sealed tube

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 100 °C / Sealed tube

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1351501-44-4
[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester

: 1610472-30-4
2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzylamine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 150 °C / Microwave irradiation

2: methanol / Reflux; Sealed tube

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 100 °C / Sealed tube

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;