benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

Base Information

Chemical Name:benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide
CAS No.:1451004-56-0
Molecular Formula:C₁₆H₁₃FN₂O
Molecular Weight:268.29
Hs Code.:

Synonyms:benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

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Chemical Property of benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

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Technology Process of benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

There total 5 articles about benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446491-73-1
2-(2-bromoethyl)-5-fluorobenzaldehyde

: 613-94-5
benzoic acid hydrazide

: 1451004-56-0
benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

Guidance literature:: 2-(2-bromoethyl)-5-fluorobenzaldehyde; benzoic acid hydrazide; In methanol;

With triethylamine; Heating;

With water;
DOI:10.1002/chem.201405191

Reference yield:

: C₁₆H₁₄FN₂O⁽¹⁺⁾*Br^(1-)

: 1451004-56-0
benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

Guidance literature:: C₁₆H₁₄FN₂O⁽¹⁺⁾*Br^(1-); With methanol; triethylamine; at 20 ℃; for 0.166667h; Inert atmosphere;

With water; at 20 ℃; for 0.5h; Inert atmosphere;

In dichloromethane; Inert atmosphere;
DOI:10.1002/chem.201601548

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 1451004-56-0
benzoyl(7-fluoro-3,4-dihydroisoquinolin-2-ium-2-yl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0 - 20 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C

5.1: trimethylsilyl bromide; tetrabutylammomium bromide / toluene / 80 °C

6.1: methanol

6.2: Heating

With lithium aluminium tetrahydride; trimethylsilyl bromide; trimethylsilyl trifluoromethanesulfonate; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1002/chem.201405191