tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane
CAS No.:340320-92-5
Molecular Formula:C₂₀H₃₀O₅Si
Molecular Weight:378.541
Hs Code.:

Synonyms:tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

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Chemical Property of tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

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Technology Process of tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

There total 2 articles about tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 273749-60-3
phenyl 4,6-O-(4-methoxybenzylidene)-1-thio-β-D-glucopyranoside

: 340320-92-5
tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / D-camphorsulfonic acid / tetrahydrofuran / 1 h / 40 °C

2: 75 percent / lithium naphtalenide / tetrahydrofuran / -78 °C

3: 97 percent / imidazole / dimethylformamide / 18 h / 23 °C

With 1H-imidazole; (1S)-10-camphorsulfonic acid; lithium dihydronaphthylide radical; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(01)00203-8

Reference yield:

: phenyl 2,3-di-O-isopropylidene-4,6-O-p-methoxybenzylidene-1-thio-β-D-glucopyranoside

: 340320-92-5
tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / lithium naphtalenide / tetrahydrofuran / -78 °C

2: 97 percent / imidazole / dimethylformamide / 18 h / 23 °C

With 1H-imidazole; lithium dihydronaphthylide radical; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(01)00203-8

Reference yield: 91.0%

: 340320-92-5
tert-butyl(((2R,4aR,8R,8aR)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)dimethylsilane

: 916154-04-6
((2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)-3,4-dihydro-2H-pyran-2-yl)methanol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -20 - 20 ℃; for 0.333333h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201203284