1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

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Chemical Name:1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate
CAS No.:867367-05-3
Molecular Formula:C₂₂H₂₀ClFN₂O₇
Molecular Weight:478.861
Hs Code.:

Synonyms:1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

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Chemical Property of 1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

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Technology Process of 1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

There total 6 articles about 1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 770719-09-0
3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile

: 32864-38-3
tert-Butyl ethyl malonate

: 867367-05-3
1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

Guidance literature:: tert-Butyl ethyl malonate; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 1h;

3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

With hydrogenchloride; water; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 770719-09-0
3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile

: 867367-05-3
1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

Guidance literature:: tert-Butyl ethyl malonate; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 1h;

3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 473923-96-5
3-chloro-5-methoxybenzonitrile

: 867367-05-3
1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

1.2: Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

3.3: 20 °C

With 2,4,6-trimethyl-pyridine; sodium hydride; lithium iodide; In tetrahydrofuran; mineral oil;