473923-96-5

Basic information

• Product Name: 3-chloro-5-methoxybenzonitrile
• Synonyms: 3-chloro-5-methoxybenzonitrile
• CAS NO: 473923-96-5
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59234
• EINECS: 604-604-1
• Mol File: 473923-96-5.mol

Chemical Properties

• Boiling Point: 241.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-chloro-5-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-methoxybenzonitrile(473923-96-5)
• EPA Substance Registry System: 3-chloro-5-methoxybenzonitrile(473923-96-5)

Safety Data

• Hazardous Substances Data: 473923-96-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-5-methoxybenzonitrile is used as a chemical intermediate for the synthesis of various drugs. Its presence in the molecular structure of target compounds allows for the development of new pharmaceuticals with potential therapeutic applications.
Used in Agricultural Chemicals Industry:
3-chloro-5-methoxybenzonitrile is used as a precursor in the production of agricultural chemicals. Its incorporation into the chemical structure of these products contributes to their effectiveness in controlling pests and diseases in crops, thereby enhancing agricultural productivity.
Used in Dyes Industry:
3-chloro-5-methoxybenzonitrile is utilized in the manufacture of dyes due to its ability to impart color to various substrates. Its chemical properties allow for the creation of dyes with specific color characteristics and stability, which are essential for applications in textiles, plastics, and other industries.
Safety Considerations:
Given its classification as a hazardous chemical, 3-chloro-5-methoxybenzonitrile may cause irritation to the skin, eyes, and respiratory system upon exposure. Therefore, it is crucial to handle and store 3-chloro-5-methoxybenzonitrile with proper precautions, including the use of personal protective equipment and adherence to safety guidelines, to ensure the well-being of individuals and the environment.

Upstream product

• 557-21-1 zinc(II) cyanide 
• 174913-12-3 1-bromo-3-chloro-5-methoxybenzene 
• 557-21-1 dicyanozinc 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 124-41-4 sodium methylate 
• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 1333152-90-1 C₉H₈ClN₃O 
• 1093988-29-4 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1093988-28-3 4-chloro-3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropylbenzenesulfonamide 
• 1093988-27-2 4-chloro-5-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-2-fluoro-N-methylbenzenesulfonamide 
• 1093988-26-1 5-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-2-methylbenzenesulfonamide 
• 1093988-25-0 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(3-hydroxypropyl)benzamide 
• 1093988-24-9 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropylbenzamide 
• 1093988-23-8 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(4-morpholinyl)ethyl]benzamide 
• 1093988-22-7 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(methylsulfonyl)ethyl]benzamide 
• 1093988-20-5 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(2,3-dihydroxypropyl)benzamide 
• 1093988-21-6 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]benzamide 
• 1093988-19-2 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]benzamide 
• 1093988-18-1 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]benzoic acid 

Relevant articles and documents

HETEROCYCLIC DERIVATIVES AND USE THEREOF

A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.

New Pharmaceutical Compounds

Compounds of formula I, wherein A and R1-R7, are as defined in the claims, exhibit TRPA1 activity and are thus useful as TRPA1 modulators.

PHENYL- SULFONYL DERIVATIVES AS MEDIATORS OF TRPA1 RECEPTOR ACTIVITY FOR THE TREATMENT OF PAIN

Compounds of formula I, wherein A and R1-R7, are as defined in the claims, exhibit TRPA1 activity and useful as TRPA1 modulators.

NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

Non-nucleoside reverse transcriptase inhibitors

Compounds of formula I, wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.