Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Base Information

Chemical Name:Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate
CAS No.:1092938-10-7
Molecular Formula:C₂₆H₂₈N₄O₃
Molecular Weight:444.533
Hs Code.:

Synonyms:Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Suppliers and Price of Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

There total 9 articles about Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1092938-08-3
Methyl 6-{[6-phenyl-5-(5-vinylpyridin-2-yl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

: 1092938-10-7
Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 4.5h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1092938-10-7
Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: acetic anhydride / di-isopropyl ether / 24 h / 0 - 130 °C

3.1: trichlorophosphate / 1 h / 20 °C / Reflux

3.2: 20 - 75 °C / pH > 9

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 160 °C

5.1: N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 7 h / 90 °C / Inert atmosphere

7.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide; methanol / 3 h / 80 °C / Inert atmosphere

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h / 20 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; hydrogen; potassium acetate; acetic anhydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; tetrachloromethane; ethanol; dichloromethane; di-isopropyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 14742-32-6
2-amino-5-phenylfuran-3-carbonitrile

: 1092938-10-7
Methyl 6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic anhydride / di-isopropyl ether / 24 h / 0 - 130 °C

2.1: trichlorophosphate / 1 h / 20 °C / Reflux

2.2: 20 - 75 °C / pH > 9

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 160 °C

4.1: N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 7 h / 90 °C / Inert atmosphere

6.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide; methanol / 3 h / 80 °C / Inert atmosphere

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h / 20 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; hydrogen; potassium acetate; acetic anhydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; tetrachloromethane; ethanol; dichloromethane; di-isopropyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;