METHYL 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETATE

Base Information

• Chemical Name: METHYL 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETATE
• CAS No.: 1233-56-3
• Molecular Formula: C₁₆H₁₇NO₄S
• Molecular Weight: 319.381
• Hs Code.: 2935009090
• Mol file: 1233-56-3.mol

Synonyms:Glycine,2-phenyl-N-(p-tolylsulfonyl)-, methyl ester (7CI,8CI); N-Tosyl-DL-phenylglycinemethyl ester

Chemical Property of METHYL 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETATE

Chemical Property:

• Vapor Pressure: 3.92E-09mmHg at 25°C
• Melting Point: 113-115°C
• Boiling Point: 473.5°Cat760mmHg
• Flash Point: 240.1°C
• PSA: 80.85000
• Density: 1.256g/cm³
• LogP: 3.65930
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-{[(4-Methylphenyl)sulfonyl]amino}-2-phenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETATE

There total 27 articles about METHYL 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-Phenylglycine methyl ester (24461-61-8) + p-toluenesulfonyl chloride (98-59-9) → (R)-2-phenylglycine methyl ester hydrochloride salt (111047-53-1,1233-56-3,111047-54-2,148152-51-6)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; Inert atmosphere;

DOI:10.1021/jo200715c

Reference yield: 94.0%

D-phenylglycine methyl ester hydrochloride (19883-41-1,13226-98-7) + p-toluenesulfonyl chloride (98-59-9) → (R)-2-phenylglycine methyl ester hydrochloride salt (111047-53-1,1233-56-3,111047-54-2,148152-51-6)

Guidance literature:

D-phenylglycine methyl ester hydrochloride; With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 0.333333h;

p-toluenesulfonyl chloride; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 15h;

DOI:10.1021/op050182n

Reference yield: 90.0%

methyl N-p-toluenesulfonyl-1-imino-1-phenylacetate (111047-52-0) → methyl 2-((4-methylphenyl)sulfonamido)-2-phenylacetate (111047-53-1,111047-54-2,148152-51-6,1233-56-3)

Guidance literature:

With aluminium trichloride; diphenylsilane; In dichloromethane; at 20 ℃; for 11h; other Lewis acids, times and temperatures;

DOI:10.1246/bcsj.63.2588

upstream raw materials:

methyl N-p-toluenesulfonyl-1-imino-1-phenylacetate

N-(2-methoxy-1-phenylbuta-2,3-dienyl)-p-toluenesulfonamide

phenyl N-tosyl imine

toluene-4-sulfonamide

Downstream raw materials:

3-[(4-methylphenyl)sulfonyl]propanoic acid ethyl ester

(R)-N-(2-hydroxy-1-phenylethyl)-4-methyl-S-methylenebenzenesulfinamide

4-methyl-N-(2-phenylethyl)benzenesulfonamide

(R)-2-phenyl-N-tosylaziridine