(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

Base Information

Chemical Name:(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane
CAS No.:188051-21-0
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

Synonyms:(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

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Chemical Property of (4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

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Technology Process of (4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

There total 2 articles about (4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 141-86-6
2.6-diaminopyridine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 188051-21-0
(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00068-3

Reference yield: 50.0%

: 141-86-6
2.6-diaminopyridine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 276241-94-2
(1S,7S)-1,7-Dibenzyl-1,7-bis(tert-butoxycarbonylamino)-3,5-diaza-4(2,6)-pyridinaheptaphane-2,6-dione

: 188051-21-0
(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1039/b912728c

Reference yield:

: 188051-21-0
(4S)-4-tert-Butoxycarbonyl-4-benzyl-3-oxo-11,4-diamino-12,2-diaza-1(1,3)-benzatetraphane

: N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / CH₂Cl₂ / 0.5 h

2: DIPEA / tetrahydrofuran / 2 h

3: 62 percent / N-methylmorpholine / tetrahydrofuran / 2 h / Heating

4: pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂; dioxane / 0.5 h / Ambient temperature

With pyrrolidine; 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W