N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

Base Information

Chemical Name:N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester
CAS No.:188051-31-2
Molecular Formula:C₄₈H₅₁N₅O₈
Molecular Weight:825.962
Hs Code.:

N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

Synonyms:N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

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Chemical Property of N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

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Technology Process of N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

There total 14 articles about N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 188051-24-3
(4S)-Prop-2-enyl-4-benzyl-3,6-dioxo-11-amino-12,2,5-diaza-1(1,3)-benzanonaphane-9-carboxylate

: 188051-29-8
1-tert-Butoxycarbonylamino-3-oxa-2(1,4),5(1,4),6(1,4)-tribenzaheptaphane-7-carboxylic acid fluoride

: 188051-31-2
N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; for 2h; Heating;
DOI:10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W

Reference yield:

: 873-75-6
4-bromobenzenemethanol

: 188051-31-2
N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

2: 94 percent / BH₃*Me₂S / tetrahydrofuran / 48 h / Heating

3: 81 percent / Et₃N / CH₂Cl₂ / 1 h

4: 1.) Bu₃SnSnBu₃ / 1.) Pd(PPh₃)4, 2.) Pd(PPh₃)2Cl₂ / 1.) toluene, reflux, 5 h, 2.) toluene, reflux, 12 h

5: 92 percent / LiOH, H₂O / dioxane / 2 h

6: 96 percent / cyanuric fluoride, pyridine / acetonitrile / Ambient temperature

7: 62 percent / N-methylmorpholine / tetrahydrofuran / 2 h / Heating

With 4-methyl-morpholine; pyridine; lithium hydroxide; trifluoro-[1,3,5]triazine; dimethylsulfide borane complex; water; bis(tri-n-butyltin); triethylamine; triphenylphosphine; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W

Reference yield:

: 155720-37-9
11-Bromo-5-amino-3-oxa-1(1,4),4(1,4)-dibenzapentaphane

: 188051-31-2
N-{(S)-1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / Et₃N / CH₂Cl₂ / 1 h

2: 1.) Bu₃SnSnBu₃ / 1.) Pd(PPh₃)4, 2.) Pd(PPh₃)2Cl₂ / 1.) toluene, reflux, 5 h, 2.) toluene, reflux, 12 h

3: 92 percent / LiOH, H₂O / dioxane / 2 h

4: 96 percent / cyanuric fluoride, pyridine / acetonitrile / Ambient temperature

5: 62 percent / N-methylmorpholine / tetrahydrofuran / 2 h / Heating

With 4-methyl-morpholine; pyridine; lithium hydroxide; trifluoro-[1,3,5]triazine; water; bis(tri-n-butyltin); triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W