diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Base Information

Chemical Name:diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate
CAS No.:528836-62-6
Molecular Formula:C₃₁H₃₈Br₂N₄O₇
Molecular Weight:738.473
Hs Code.:

Synonyms:diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Suppliers and Price of diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

There total 10 articles about diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 528836-50-2
diallyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

: 528836-62-6
diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: With lithium bromide; In tetrahydrofuran; Heating;
DOI:10.1021/jm020462i

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 528836-62-6
diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2.1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

4.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

5.1: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

6.1: 28 percent / N,N-dimethyl-acetamide / 120 h / 20 °C

7.1: 93.6 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

8.1: 100 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

9.1: 64 percent / LiBr / tetrahydrofuran / Heating

With 1H-imidazole; dmap; triethylamine trihydrofluoride; hydrogen; sodium hydride; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i

Reference yield:

: 304015-62-1
N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine

: 528836-62-6
diallyl 4-{N-[4'-bis(2''-bromoethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

2.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

3.1: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

4.1: 28 percent / N,N-dimethyl-acetamide / 120 h / 20 °C

5.1: 93.6 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

6.1: 100 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

7.1: 64 percent / LiBr / tetrahydrofuran / Heating

With dmap; triethylamine trihydrofluoride; hydrogen; sodium hydride; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1021/jm020462i