Technology Process of 6-(4-acetylphenyl)-2,2-dimethylhexanenitrile
There total 3 articles about 6-(4-acetylphenyl)-2,2-dimethylhexanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-bromo-2,2-dimethylhexanenitrile;
With
indium(III) chloride; magnesium; lithium chloride;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
para-bromoacetophenone;
With
bis-triphenylphosphine-palladium(II) chloride;
In
N,N-dimethyl acetamide;
at 80 ℃;
for 12h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/chem.201203795
- Guidance literature:
-
With
lithium bromide;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
Flow reactor;
Inert atmosphere;
DOI:10.1039/c6cy00331a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 0.08 h / 20 °C / Glovebox; Inert atmosphere
1.2: 16 h / 80 °C / Glovebox; Inert atmosphere
2.1: lithium bromide / tetrahydrofuran / 16 h / 20 °C / Flow reactor; Inert atmosphere
With
lithium bromide;
In
tetrahydrofuran;
2.1: |Negishi Coupling;
DOI:10.1039/c6cy00331a
