tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

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Chemical Name:tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate
CAS No.:171051-35-7
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

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Chemical Property of tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

There total 11 articles about tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 171050-40-1
3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-one

: 171051-36-8
tert-butyl 2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-(E)-cyclohexylidene-1-acetate

: 171051-35-7
tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

: 171051-34-6
tert-butyl 2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

Guidance literature:: tert-butyl diethylphosphonoacetate; With sodium hydride; In toluene; at 4 ℃; for 0.5h;

3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-one; In toluene; at 24 ℃; for 24h;
DOI:10.1016/S0040-4020(99)00590-6

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 171050-40-1
3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-one

: 171051-35-7
tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

: 171051-34-6
tert-butyl 2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

Guidance literature:: With sodium hydride; In toluene; at 20 ℃; for 68h;

Reference yield:

: 131185-06-3
3-(3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo<1,5-a>pyridine

: 171051-35-7
tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / sodium hydroxide; benzyltriethylammonium chloride / H₂O; toluene / 18 h / Heating

2.1: 88 percent / dimethyl sulfoxide; oxalyl chloride; triethylamine / CH₂Cl₂ / -70 - 20 °C

3.1: potassium tert-butoxide; 18-crown-6 / toluene / 0.5 h / 4 °C

3.2: 21 percent / toluene / 8 h / 20 °C

4.1: DBU / toluene / 24 h / Heating

With sodium hydroxide; oxalyl dichloride; 18-crown-6 ether; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; water; toluene; 1.1: Addition / 2.1: Swern oxidation / 3.1: Metallation / 3.2: Horner-Emmons reaction / 4.1: Isomerization;
DOI:10.1016/S0040-4020(99)00590-6