N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

Base Information

Chemical Name:N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide
CAS No.:1616100-99-2
Molecular Formula:C₂₂H₂₀F₂N₄O₂S
Molecular Weight:442.489
Hs Code.:

Synonyms:N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

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Chemical Property of N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

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Technology Process of N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

There total 5 articles about N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,3S)-3-amino-3-(2,4-difluorophenyl)-1-(pyrimidin-5-yl)butan-1-ol hydrochloride

: 532-55-8
Benzoyl isothiocyanate

: 1616100-99-2
N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1585971-57-8
(R,E)-N-(1-(2,4-difluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1616100-99-2
N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / -10 - -5 °C / Inert atmosphere

2.1: lithium tri-t-butoxyaluminum hydride / diethyl ether; tetrahydrofuran / 1 h / -78 - -50 °C / Inert atmosphere

3.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1616100-97-0
(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

: 1616100-99-2
N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;