(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1616100-97-0
Molecular Formula:C₁₈H₂₃F₂N₃O₂S
Molecular Weight:383.462
Hs Code.:

Synonyms:(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1616100-96-9
(R)-N-((S)-2-(2,4-difluorophenyl)-4-oxo-4-(pyrimidin-5-yl)-butan-2-yl)-2-methylpropane-2-sulfinamide

: 1616100-97-0
(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether; at -78 - -50 ℃; for 1h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01012

Reference yield:

: 364-83-0
2',4'-difluoroacetophenone

: 1616100-97-0
(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 65 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 1.5 h / -10 - -5 °C / Inert atmosphere

3.1: lithium tri-t-butoxyaluminum hydride / diethyl ether; tetrahydrofuran / 1 h / -78 - -50 °C / Inert atmosphere

With titanium(IV) tetraethanolate; sodium hydride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1585971-57-8
(R,E)-N-(1-(2,4-difluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1616100-97-0
(R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(pyrimidin-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / -10 - -5 °C / Inert atmosphere

2.1: lithium tri-t-butoxyaluminum hydride / diethyl ether; tetrahydrofuran / 1 h / -78 - -50 °C / Inert atmosphere

With sodium hydride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;