4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene

Base Information

Chemical Name:4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene
CAS No.:171011-38-4
Molecular Formula:C₂₀H₃₇BrO₂Si₂
Molecular Weight:445.588
Hs Code.:
DSSTox Substance ID:DTXSID101156302

Synonyms:SCHEMBL4513196;DTXSID101156302;4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene;171011-38-4

Suppliers and Price of 4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:444.15155
Heavy Atom Count:25
Complexity:424

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1=C(C=C(C=C1)Br)CO[Si](C)(C)C(C)(C)C

Technology Process of 4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene

There total 3 articles about 4-Bromo-1,2-bis[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 171011-37-3
4-bromo-2-(hydroxymethyl)benzyl alcohol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 171011-38-4
3,4-bis<<(tert-butyldimethylsilyl)oxy>methyl>-1-bromobenzene

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/jm00022a019

Reference yield:

: 87639-57-4
4-bromophthalic Acid Dimethyl Ester

: 171011-38-4
3,4-bis<<(tert-butyldimethylsilyl)oxy>methyl>-1-bromobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / a) RT, 1 h, b) reflux, 1.5 h

2: 98 percent / 4-(dimethylamino)pyridine, triethylamine / dimethylformamide; tetrahydrofuran / 2 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a019

Reference yield:

: 6968-28-1
4-bromophthalic acid

: 171011-38-4
3,4-bis<<(tert-butyldimethylsilyl)oxy>methyl>-1-bromobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / -40 - 0 °C

2: dmap; 1H-imidazole / dichloromethane / 20 °C

With 1H-imidazole; dmap; borane-THF; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.07.037