O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester

Base Information

• Chemical Name: O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester
• CAS No.: 1058150-76-7
• Molecular Formula: C₅₁H₅₂N₁₀O₁₈P₂
• Molecular Weight: 1154.98

Synonyms:O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester

Chemical Property of O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester

Chemical Property:

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98% ^*data from raw suppliers

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Technology Process of O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester

There total 1 articles about O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphoric acid bis-(2-cyano-ethyl) ester 3-hydroxy-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-2-ylmethyl ester + N4,2',3'-O,O-tribenzoylcytidin-5'-yl hydrogenophosphonate, triethylammonium salt (1058150-71-2) → O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester (1058150-76-7)

Guidance literature:

With pyridine; PS acyl chloride resin; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm800617c

Reference yield:

O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester (1058150-76-7) + methyl 6-aminocaproate hydrochloride (1926-80-3) → C58H65N11O20P2

Guidance literature:

With pyridine; tetrachloromethane; triethylamine; at 20 ℃; for 1h;

DOI:10.1021/jm800617c

Reference yield:

O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyanoethyl)phosphoryl]guanosin-3'-yl} hydrogenphosphonate diester (1058150-76-7) + 1-amino-3-(dimethylamino)propane (109-55-7) → C56H64N12O18P2

Guidance literature:

With pyridine; tetrachloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm800617c

upstream raw materials:

N₄,2',3'-O,O-tribenzoylcytidin-5'-yl hydrogenophosphonate, triethylammonium salt

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