3-Dimethylaminopropylamine

Base Information

• Chemical Name: 3-Dimethylaminopropylamine
• CAS No.: 109-55-7
• Deprecated CAS: 68497-58-5,1190921-64-2
• Molecular Formula: C5H14N2
• Molecular Weight: 102.18
• Hs Code.: 2921.29
• European Community (EC) Number: 203-680-9
• ICSC Number: 1227
• NSC Number: 1067
• UN Number: 2734,1993
• UNII: I98I2UEC03
• DSSTox Substance ID: DTXSID5025102
• Nikkaji Number: J50.732F
• Wikipedia: Dimethylaminopropylamine
• Wikidata: Q5277328
• RXCUI: 1661327
• ChEMBL ID: CHEMBL1232234
• Mol file: 109-55-7.mol

Synonyms:3-(dimethylamino)-1-propylamine;3-dimethylaminopropylamine;3-dimethylaminopropylamine, conjugate diacid;dimethylpropanediamine;DMAPA propylamine;N,N-dimethyl-1,3-propanediamine;N1,N1-dimethyl-1,3-propylenediamine

Chemical Property of 3-Dimethylaminopropylamine

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 5 mm Hg ( 20 °C)
• Melting Point: -60 °C
• Refractive Index: 1.4350
• Boiling Point: 107.8 °C at 760 mmHg
• PKA: 10.13±0.10(Predicted)
• Flash Point: 9.1 °C
• PSA: 29.26000
• Density: 0.803 g/cm³
• LogP: 0.59710
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive
• Water Solubility.: SOLUBLE
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 102.115698455
• Heavy Atom Count: 7
• Complexity: 35.1
• Transport DOT Label: Corrosive Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethyl-1,3-propylenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-22-34-43-21/22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN(C)CCCN
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Medical observation is indicated.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization.
• Description: Dimethylaminopropylamine is an aliphatic amine present in amphoteric surfactants such as liquid soaps and shampoos. It is present as an impurity responsible for allergy from cocamidopropylbetaine. It is structurally similar to diethylaminopropylamine. It is also used as a curing agent for epoxy res ins and as an organic intermediate in chemical syntheses (ion exchangers, additives for flocculants, cosmetics and fuel additives, dyes and pesticides).
• Uses: N,N-Dimethyl-1,3-propylenediamine is a useful catalyst for Knoevenagel condensation. It is also a useful hardening agent for expoxy resin. Useful for cleavage of N-alkylphthalimide derivatives to give primary amines, as an alternative to methyl hydrazine. DMAPA is also used directly as a hardener in epoxy resins in the plastics industry, as a cross linking agent for cellulose fibers in the paper industry and as an anti-shriking agent for leather. It is used as an intermediate in the production of binding agents, ion-exchange materials, flocculating agents (water treatment), cosmetic agents, washing and cleaning agents (betaines), additive for petrol and other fuels, polyurethane fibers and lubricants, dyes, agrochemicals, agents used in the photographic and textile industries. 3-(Dimethylamino)propylamine is an intermediate substance in the synthesis of alkylamidopropyldimethylamines/alkylamidobetaines; found as an impurity in cosmetic surfactants present in e.g. shampoos; hardener of epoxy resins; additive in fue!, dyes, pesticides and binding agents; in the production of ion-exchangers.

Technology Process of 3-Dimethylaminopropylamine

There total 23 articles about 3-Dimethylaminopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.98%

α-(dimethylamino)-propionitrile (5350-67-4) → propylamine (107-10-8,42939-71-9) + N,N,N'N'-tetramethyl-1,3-propanediamine (110-95-2) + 1-amino-3-(dimethylamino)propane (109-55-7) + N,N-bis-(3-dimethylaminopropyl)amine (6711-48-4,86003-72-7)

Guidance literature:

With caustic; hydrogen; nickel catalyst Degussa MC₅₀₂; In water; at 90 ℃; for 0.45h; under 5932.2 Torr; Product distribution / selectivity;

Reference yield: 99.98%

3-dimethylaminopropiononitrile (1738-25-6) → 1-amino-3-(dimethylamino)propane (109-55-7)

Guidance literature:

With potassium hydroxide; sodium hydroxide; hydrogen; Ni-MC₅₀₂; In water; at 90 ℃; under 5932.2 Torr;

Reference yield: 71.0%

→ N,N-8-Triethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,49 triazolo[1,5-a]pyrimidin-5-amine + 1-amino-3-(dimethylamino)propane (109-55-7)

Guidance literature:

upstream raw materials:

3-aminopropyl hydrogen sulfate

dimethyl amine

3-dimethylaminopropiononitrile

N,N-dimethyl-N-(3-phthalimidopropyl)amine

Downstream raw materials:

N,N-dimethyl-N-(3-phthalimidopropyl)amine

N⁴-(3-dimethylamino-propyl)-5,6-dimethyl-pyrimidine-2,4-diyldiamine

5-oxo-4,4-diphenyl-hexanoic acid-(3-dimethylamino-propylamide)

N²,N⁴-bis-(3-dimethylamino-propyl)-6,7-diphenyl-pteridine-2,4-diyldiamine

Refernces

• 1、 Nudelman, Norma Sbarbati,Alvaro, Cecilia E. Silvana. "Inter- and intramolecular hydrogen bonds in polyamines: Variable-concentration 1H-NMR studies". . p. 1067 - 1071. Retrieved 2011.
• 2、 Ciaccia, Maria,Tosi, Irene,Baldini, Laura,Cacciapaglia, Roberta,Mandolini, Luigi,Di Stefano, Stefano,Hunter, Christopher A.. "Applications of dynamic combinatorial chemistry for the determination of effective molarity". . p. 144 - 151. Retrieved 2015/02/19.
• 3、 -. "DMAPN Having a Low DGN Content and a Process for Preparing DMAPA from DMAPN Having a Low DGN Content". Page/Page column 6-7. . Retrieved 2012/02/06.