(S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester

Base Information

• Chemical Name: (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester
• CAS No.: 73096-21-6
• Molecular Formula: C₁₂H₁₂N₂O₆
• Molecular Weight: 280.237
• Mol file: 73096-21-6.mol

Synonyms:(S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester

Chemical Property of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester

There total 2 articles about (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitrophenyl chloroformate (7693-46-1) → (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester (73096-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2: tetrahydrofuran / 50 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1246/cl.2003.830

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) + N-(4-nitrophenoxycarbonyloxy)succinimide (371783-15-2) → (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester (73096-21-6)

Guidance literature:

In tetrahydrofuran; at 50 ℃;

DOI:10.1246/cl.2003.830

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + phenethylamine (64-04-0) + (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester (73096-21-6) → (S)-1-tert-butyl 2-[(2-phenylethyl)carbamoyl]pyrrolidine-1-carboxylate (92122-49-1)

Guidance literature:

phenethylamine; (S)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-phenyl) ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; In N,N-dimethyl-formamide; for 1.5h;

DOI:10.1246/cl.2003.830

upstream raw materials:

L-proline

N-(4-nitrophenoxycarbonyloxy)succinimide

4-Nitrophenyl chloroformate

Downstream raw materials:

(S)-1-tert-butyl 2-[(2-phenylethyl)carbamoyl]pyrrolidine-1-carboxylate