Reduced reduced midazolam

Base Information

Chemical Name:Reduced reduced midazolam
CAS No.:59469-08-8
Molecular Formula:C₁₈H₁₇ClFN₃
Molecular Weight:329.804
Hs Code.:
UNII:AH884ZF6QL

Synonyms:Reduced reduced midazolam;59469-08-8;AH884ZF6QL;UNII-AH884ZF6QL;Midazolam impurity J [EP];3H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-3a,4,5,6-tetrahydro-1-methyl-;8-Chloro-6-(2-fluorophenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-imidazo(1,5-a)(1,4)benzodiazepine;8-chloro-6-(2-fluorophenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-imidazo[1,5-a][1,4]benzodiazepine;8-Chloro-6-(2-fluorophenyl)-3a,4,5,6-tetrahydro-1-methyl-3H-imidazo(1,5-a)(1,4)benzodiazepine;Midazolam Imp. J (EP);Midazolam Impurity J;SCHEMBL7307499;3a,4,5,6-Tetrahydro Midazolam;MIDAZOLAM IMPURITY J [EP IMPURITY]

Suppliers and Price of Reduced reduced midazolam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Reduced reduced midazolam

Chemical Property:

Boiling Point:428.5±55.0 °C(Predicted)
Density:1.37±0.1 g/cm3(Predicted)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:329.1095034
Heavy Atom Count:23
Complexity:471

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NCC2N1C3=C(C=C(C=C3)Cl)C(NC2)C4=CC=CC=C4F
Uses Midazolam EP Impurity J is an impurity of Midazolam (M343000), a drug used for the treatment of acute seizures and is also known t o exhibit activities as an anticonvulsant, sedative, and hypnotic.

Technology Process of Reduced reduced midazolam

There total 5 articles about Reduced reduced midazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59467-69-5
8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine

: 59469-08-8
8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[5,1-a][1,4]diazepine

Guidance literature:: With potassium hydroxide; acetic acid; zinc; In dichloromethane;

Reference yield:

: 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2-(1-nitromethylene)-2H-1,4-benzodiazepine 4-oxide

: 59469-08-8
8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[5,1-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum nickel / tetrahydrofuran; methanol

2: PPA; acetic anhydride / methanol; dichloromethane; water

3: hydrogen / dichloromethane; water; acetic acid; Petroleum ether

With PPA; hydrogen; acetic anhydride; aluminum nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; Petroleum ether;

Reference yield:

: 59467-64-0
(7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine

: 59469-08-8
8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[5,1-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: PPA; acetic anhydride / methanol; dichloromethane; water

2: hydrogen / dichloromethane; water; acetic acid; Petroleum ether

With PPA; hydrogen; acetic anhydride; In methanol; dichloromethane; water; acetic acid; Petroleum ether;