Chemical Property of Diphemanil methylsulfate
Chemical Property:
- Melting Point:194-195 °C
- PSA：74.81000
- LogP:4.49130
- Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
- Water Solubility.:Soluble in water
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:389.16607952
- Heavy Atom Count:27
- Complexity:426
- Purity/Quality:
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99%, *data from raw suppliers
DiphemanilMethosulfate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]
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Description
Diphemanil is a quaternary ammonium anticholinergic agent. It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC50 = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; ) in vagotomized cats (ED50s = 17.5 and 19.3 μg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.
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Uses
Diphemanil Methosulfate is an anticholinergic agent; a synthetic quaternary ammonium compound with anitmuscarinic properties used in the treatment of Frey''s syndrome and is used as a parasympatholytic bronchodilator agent. Bronchodilatator;Anticholinergic
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Therapeutic Function
Spasmolytic
