4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole

Base Information Edit

Chemical Name:4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole
CAS No.:1037797-53-7
Molecular Formula:C₁₆H₁₈N₆OS
Molecular Weight:342.425
Hs Code.:
Mol file:1037797-53-7.mol

Synonyms:4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole

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Chemical Property of 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole Edit

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Technology Process of 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole

There total 3 articles about 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1037791-31-3
4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester

: 1037797-53-7
4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole

Guidance literature:: 4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; methanol; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In water; at 10 ℃; Product distribution / selectivity;

Reference yield:

: 39546-32-2
4-carboxamidopiperidine

: 1037797-53-7
4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 2 h / 20 °C

2.1: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C

3.1: magnesium sulfate; magnesium carbonate / acetone / Reflux

4.1: potassium iodide; caesium carbonate / acetonitrile / Reflux

5.1: tert-butyl carbazate / dichloromethane / 20 °C / Inert atmosphere

5.2: 15.5 h / 0 - 20 °C

With Lawessons reagent; tert-butyl carbazate; magnesium sulfate; caesium carbonate; potassium iodide; magnesium carbonate; dmap; In 1,2-dimethoxyethane; dichloromethane; acetone; acetonitrile;