(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Base Information

Chemical Name:(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
CAS No.:177706-81-9
Molecular Formula:C₂₇H₃₅NO₂
Molecular Weight:405.58
Hs Code.:

Synonyms:(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

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Chemical Property of (3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

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Technology Process of (3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

There total 8 articles about (3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 56613-80-0
D-2-phenylglycinol

: 177706-80-8
4-oxo-13-phenyltridecanoic acid

: 177706-81-9
(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: In toluene; for 15h; Heating;
DOI:10.3987/COM-95-7293

Reference yield:

: 4224-70-8
6-bromohexanoic acid

: 177706-81-9
(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: Multi-step reaction with 8 steps

1: 27.1 g / NaI / acetone / 7 h

2: 25.3 g / methanol; diethyl ether

3: 1.) Mg, 2.) CuI, 1.5M CH₃Li / 1.) THF, 2.) THF, ether, -78 deg C, 1 h, -78 to 10 deg C, 3.) THF, ether, -78 deg C, 1 h, room temp., 20 h

4: 95 percent / LiAlH₄ / tetrahydrofuran

5: 83 percent / 48percent HBr, conc. H₂SO₄ / 3 h / Heating

6: 1.) Mg, 2.) CuI, 1.6M CH₃Li / 1.) THF, 2.) THF, ether, -78 deg C, 3.) THF, ether, -78 deg C

7: 89 percent / KOH / methanol; H₂O / 20 h / 20 °C

8: 96 percent / toluene / 15 h / Heating

With potassium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; methyllithium; magnesium; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; water; acetone; toluene;
DOI:10.3987/COM-95-7293

Reference yield:

: 4224-63-9
6-iodohexanoic acid

: 177706-81-9
(3R,7aS)-3-Phenyl-7a-(9-phenyl-nonyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: 25.3 g / methanol; diethyl ether

2: 1.) Mg, 2.) CuI, 1.5M CH₃Li / 1.) THF, 2.) THF, ether, -78 deg C, 1 h, -78 to 10 deg C, 3.) THF, ether, -78 deg C, 1 h, room temp., 20 h

3: 95 percent / LiAlH₄ / tetrahydrofuran

4: 83 percent / 48percent HBr, conc. H₂SO₄ / 3 h / Heating

5: 1.) Mg, 2.) CuI, 1.6M CH₃Li / 1.) THF, 2.) THF, ether, -78 deg C, 3.) THF, ether, -78 deg C

6: 89 percent / KOH / methanol; H₂O / 20 h / 20 °C

7: 96 percent / toluene / 15 h / Heating

With potassium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; methyllithium; magnesium; In tetrahydrofuran; methanol; diethyl ether; water; toluene;
DOI:10.3987/COM-95-7293