2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

Base Information

Chemical Name:2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide
CAS No.:1350708-05-2
Molecular Formula:C₁₈H₁₈N₄O₂
Molecular Weight:322.367
Hs Code.:

Synonyms:2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

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Chemical Property of 2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

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Technology Process of 2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

There total 8 articles about 2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1350712-69-4
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

: 1350708-05-2
2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

Guidance literature:: 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide; With trifluoroacetic acid; In dichloromethane; for 2h;

With ethylenediamine; In dichloromethane; for 1h;

Reference yield:

: 1350712-68-3
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

: 1350708-05-2
2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 38 h / 150 °C / Inert atmosphere; Sealed tube

2.1: trifluoroacetic acid / dichloromethane / 2 h

2.2: 1 h

With potassium phosphate; trifluoroacetic acid; palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In dichloromethane; toluene;

Reference yield:

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

: 1350708-05-2
2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (1-cyclopropyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 0.25 h / 0 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h

3.1: potassium phosphate / palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 38 h / 150 °C / Inert atmosphere; Sealed tube

4.1: trifluoroacetic acid / dichloromethane / 2 h

4.2: 1 h

With dmap; sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; aminosulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; dichloromethane; water; toluene;