2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Base Information

Chemical Name:2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
CAS No.:1185428-34-5
Molecular Formula:C₁₃H₁₈BrN₃O₂Si
Molecular Weight:356.294
Hs Code.:
Mol file:1185428-34-5.mol

Synonyms:2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

Suppliers and Price of 2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 95+%
1g
$ 528.00

Chemenu
2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 95%
1g
$ 498.00

Alichem
2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5h-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
1g
$ 606.96

Total 3 raw suppliers

Chemical Property of 2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Chemical Property:

Boiling Point:421.6±45.0 °C(Predicted)
PKA:-1.31±0.30(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

There total 10 articles about 2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1185428-32-3
2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde; With sodium hydride; In N,N-dimethyl-d₆-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

Reference yield:

: 1184926-29-1
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

: 3724-43-4,149409-22-3
Vilsmeier reagent

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

: 1334674-89-3
2-chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: In chloroform; at 20 ℃; for 8h; Reflux; Inert atmosphere;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran

2.2: pH 4

3.1: Jones reagent / water; acetone / 0.25 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

With Jones reagent; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; mineral oil;