N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

Base Information

Chemical Name:N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide
CAS No.:1246247-65-3
Molecular Formula:C₄₈H₄₉F₇N₄O₆
Molecular Weight:910.929
Hs Code.:

N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

Synonyms:N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

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Chemical Property of N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

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Technology Process of N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

There total 14 articles about N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.8%

: 619-21-6
m-formylphenyl benzoic acid

: 1246246-70-7
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

: 1246247-65-3
N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

Guidance literature:: m-formylphenyl benzoic acid; 2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 15h; Cooling with ice; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; Cooling with ice;

Reference yield:

: 1246246-58-1
(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-5-(4-fluorophenyl)-1,3-oxazolidine

: 1246247-65-3
N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

5.2: 1 h / 20 °C / Cooling with ice

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / Cooling with ice; Inert atmosphere

6.2: Cooling with ice

With dmap; tetrabutyl ammonium fluoride; water; pivaloyl chloride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1246246-61-6
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethanol

: 1246247-65-3
N-(3-[({[(2S)-1'-(2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-3-formyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

2.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

4.2: 1 h / 20 °C / Cooling with ice

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / Cooling with ice; Inert atmosphere

5.2: Cooling with ice

With dmap; water; pivaloyl chloride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; acetonitrile;