2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

Base Information

Chemical Name:2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide
CAS No.:1246246-70-7
Molecular Formula:C₄₀H₄₅F₇N₄O₄
Molecular Weight:778.811
Hs Code.:

2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

Synonyms:2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

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Chemical Property of 2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

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Technology Process of 2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

There total 13 articles about 2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1246246-69-4
{[(2S)-1-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetic acid

: 111-33-1
1,3-bis(methylamino)propane

: 1246246-70-7
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

Guidance literature:: {[(2S)-1-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetic acid; With pivaloyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Cooling with ice;

1,3-bis(methylamino)propane; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 1246246-61-6
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethanol

: 1246246-70-7
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

2.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

4.2: 1 h / 20 °C / Cooling with ice

With dmap; water; pivaloyl chloride; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1246246-58-1
(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-5-(4-fluorophenyl)-1,3-oxazolidine

: 1246246-70-7
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

5.2: 1 h / 20 °C / Cooling with ice

With dmap; tetrabutyl ammonium fluoride; water; pivaloyl chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;