(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester
• CAS No.: 131043-58-8
• Molecular Formula: C₃₄H₂₆F₇N₃O₈
• Molecular Weight: 737.585

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester

There total 4 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-10-en-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (1S,7S,10S,11S)-1-Fluoro-10,11-dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.2.02,6]undec-8-ene-3,5-dione (131065-64-0) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.02,6]undec-10-en-8-yl ester (131043-58-8)

Guidance literature:

With pyridine;

DOI:10.1021/ja00002a040

Reference yield:

fluorobenzene (462-06-6) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.02,6]undec-10-en-8-yl ester (131043-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene dioxygenase from intact cells of Pseudomonas putida UV₄, O₂

2: 73 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: DMAP, pyridine / 48 h / 60 °C

With pyridine; dmap; toluene dioxygenase from intact cells of Pseudomonas putida UV₄; oxygen; In dichloromethane;

Reference yield:

cis-1,2-dihydroxy-3-fluorocyclohexa-3,5-diene (131101-27-4) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,7S,8S,9S)-7-fluoro-3,5-dioxo-4-phenyl-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-2,4,6-triaza-tricyclo[5.2.2.02,6]undec-10-en-8-yl ester (131043-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: DMAP, pyridine / 48 h / 60 °C

With pyridine; dmap; In dichloromethane;

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(1S,7S,10S,11S)-1-Fluoro-10,11-dihydroxy-4-phenyl-2,4,6-triaza-tricyclo[5.2.2.0^2,6]undec-8-ene-3,5-dione

fluorobenzene

4-Phenyl-1,2,4-triazolidine-3,5-dione

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